Devices for the early diagnosis of corneal diseases

Applied research in the service of the clinical innovation

Optical microscope image of the corneal tissue

The cornea

The cornea is the transparent outer tissue and the main optics of the human eye. Any alteration of the corneal integrity can strongly impair vision. The corneal tissue is made ​​up of five superimposed layers which, from the outside inwards, are represented epithelium, Bowman’s membrane, stroma, Descemet’s membrane and the endothelium.

The epithelium is formed by a series of overlapping cell layers; it is able to regenerate through the activity of the limbal stem cells. The stroma is the most important portion of the corneal tissue and maintain the mechanical and optical properties of the tissue. The endothelium is constituted by a single layer of cells whose function is to maintain the proper state of hydration of the tissue.

Corneal biomechanics

The alterations of the integrity and/or the transparency of the corneal tissue represent the third global cause of blindness in the world. Trauma, infection or genetic disorders can impair the proper functioning of the tissue and cause the loss of its transparency of the cornea. Any alteration of the corneal function is intrisecally associated with pathologic changes of the corneal biomechanics.

Our project

Vision Engineering Italy srl is developing a series of studies with the purpose to find a new solution for early diagnosis of corneal diseases. The study, conducted in collaboration with the most important centers of research in the field of biophotonics and ocular imaging in Europe.