{"id":1031,"date":"2018-07-27T13:12:55","date_gmt":"2018-07-27T13:12:55","guid":{"rendered":"\/\/www.visioeng.it\/lottica-adattiva-per-la-diagnosi-precoce-della-malattie-della-retina-e-del-nervo-ottico\/"},"modified":"2020-11-03T16:11:24","modified_gmt":"2020-11-03T16:11:24","slug":"methods-and-devices-of-early-diagnosis-of-retinal-diseases","status":"publish","type":"page","link":"https:\/\/www.visioeng.it\/en\/methods-and-devices-of-early-diagnosis-of-retinal-diseases\/","title":{"rendered":"Methods and devices of early diagnosis of retinal diseases"},"content":{"rendered":"<div class=\"aux-vc-wrapper\" >[vc_section][vc_row][vc_column][vc_column_text]\n<h1 style=\"text-align: center;\">Methods and devices of early diagnosis of retinal diseases<\/h1>\n[\/vc_column_text][\/vc_column][\/vc_row][vc_row gap=&#8221;30&#8243;][vc_column offset=&#8221;vc_col-lg-offset-1 vc_col-lg-5 vc_col-md-offset-2 vc_col-md-8 vc_col-sm-offset-0 vc_col-xs-12&#8243;][vc_column_text]<section class=\"aux-bus2-image-green-gradiant-reverse aux-bus2-image-radius-10px widget-container aux-widget-image aux-alignnone aux-parent-au32afb7e2\" style=\"\" >\n    <div class=\"aux-media-hint-frame \">\n        <div class=\"aux-media-image \" >\n        \n            \n\n                            <div class='aux-hover-scale-circle-plus'>\n                    <span class='aux-symbol-plus'><\/span>\n                    <span class='aux-symbol-circle'><\/span>\n                <\/div>\n            \n            <img width=\"777\" height=\"697\" src=\"https:\/\/www.visioeng.it\/wp-content\/uploads\/ottica_a-777x697.jpg\" class=\"aux-attachment aux-featured-image aux-attachment-id-634\" alt=\"ottica_a\" srcset=\"https:\/\/www.visioeng.it\/wp-content\/uploads\/ottica_a-200x179.jpg 200w,https:\/\/www.visioeng.it\/wp-content\/uploads\/ottica_a-500x449.jpg 500w,https:\/\/www.visioeng.it\/wp-content\/uploads\/ottica_a-768x689.jpg 768w,https:\/\/www.visioeng.it\/wp-content\/uploads\/ottica_a-1024x919.jpg 1024w,https:\/\/www.visioeng.it\/wp-content\/uploads\/ottica_a-777x697.jpg 777w\" data-ratio=\"1.11\" data-original-w=\"1920\" sizes=\"(max-width:479px) 480px,(max-width:767px) 768px,(max-width:1023px) 1024px,777px\" \/>            \n                <\/div>\n    <\/div>\n\n<\/section><!-- widget-container -->[\/vc_column_text][\/vc_column][vc_column el_class=&#8221;aux-bus2-projects-column&#8221; offset=&#8221;vc_col-lg-offset-0 vc_col-lg-5 vc_col-md-offset-2 vc_col-md-8 vc_col-sm-offset-0 vc_col-xs-12&#8243;][vc_column_text]<section class=\"aux-bus2-projects-text aux-bus2-green-btn aux-parallax widget-container aux-widget-text aux-parent-au97bc856a\" style=\"\" >        <div class=\"aux-widget-advanced-text aux-wrap-style-simple aux-ico-pos-top aux-text-left aux-text-resp-left aux-text-color-dark aux-text-widget-bg-center  \" style=\"background-color: #f9f9f9; \">\n        \n            \n            <div class=\"aux-text-inner aux-text-widget-content\">\n                                <div class=\"widget-content\">\n                                        \n<h3>Adaptive optics retinal imaging<\/h3>\n<div class=\"aux-bus2-title-divider\"><\/div>\n<p>\u00a0<\/p>\n<p>The future for early detection of the most frequent ocular diseases<br \/>\n                <\/div>\n                            <\/div>\n        <\/div>\n                    <div class=\"aux-text-widget-footer\">\n                <div class=\"aux-border-shape-none \">\n                                <\/div>\n            <\/div>\n        \n<\/section><!-- widget-container -->[\/vc_column_text][\/vc_column][\/vc_row][vc_row css=&#8221;.vc_custom_1532705427259{margin-bottom: 110px !important;}&#8221;][vc_column width=&#8221;1\/2&#8243;][vc_column_text]Vision Engineering Italy is committed to the development of computerized methods for early detection of retinal diseases.[\/vc_column_text][vc_column_text]<div id=\"accordions-1034\" class=\"accordions-1034 accordions\">\r\n                <style type='text\/css'>\r\n        @media only screen and (min-width: 1024px ){\r\n            #accordions-1034 {\r\n                            width: 100%;\r\n                        }\r\n        }\r\n        @media only screen and ( min-width: 768px ) and ( max-width: 1023px ) {\r\n            #accordions-1034 {\r\n                            width: 100%;\r\n                        }\r\n        }\r\n        @media only screen and ( min-width: 0px ) and ( max-width: 767px ){\r\n            #accordions-1034 {\r\n                            width: 100%;\r\n                        }\r\n        }\r\n        #accordions-1034 {\r\n                            text-align: left;\r\n                                                position: relative;\r\n        }\r\n        #accordions-1034 .accordions-head{\r\n                    background:#1bb0ce none repeat scroll 0 0;\r\n                                    outline: none;\r\n        }\r\n        #accordions-1034 .accordions-head-title{\r\n                            color:#ffffff;\r\n                            font-size:14px;\r\n                }\r\n        #accordions-1034 .accordions-head-title-toggle{\r\n                    color:#ffffff;\r\n                            font-size:14px;\r\n                }\r\n        #accordions-1034 .accordions-head:hover .accordions-head-title{\r\n                    color:#ffffff;\r\n                }\r\n        #accordions-1034 .ui-state-active{\r\n                    background: #00b3c0;\r\n                    border: none;\r\n        }\r\n        #accordions-1034 .accordion-content{\r\n                                    color:#333333;\r\n                            font-size:13px;\r\n                                    border: none;\r\n        }\r\n        #accordions-1034 .accordion-icons{\r\n                        color:#ffffff;\r\n                                    font-size:14px;\r\n                                                            margin:0px;\r\n                    }\r\n        #accordions-1034 .accordions-head:hover .accordion-icons span{\r\n                    }\r\n        #accordions-1034{}\r\n#accordions-1034 .accordions-head{font-family: &quot;Ubuntu&quot;; font-size: 1.375em; letter-spacing: 0;\r\n    font-weight: 600;}\r\n#accordions-1034 .accordion-content{font-family: &quot;Roboto&quot;; font-size: 1em; color: #444; line-height: 1.5;\r\n    font-style: normal;}    <\/style>\r\n    <div class=\"items\">\r\n                        <div post_id=\"1034\" itemcount=\"0\" header_id=\"header-1536576333082\" id=\"header-1536576333082\" style=\"\" class=\"accordions-head head1536576333082 border-none\" toggle-text=\"\" main-text=\"Adaptive Optics in Ophthalmology\">\r\n                                            <span id=\"accordion-icons-1536576333082\" class=\"accordion-icons\">\r\n                            <span class=\"accordion-icon-active accordion-plus\"><i class=\"fa fa-plus\"><\/i><\/span>\r\n                            <span class=\"accordion-icon-inactive accordion-minus\"><i class=\"fa fa-minus\"><\/i><\/span>\r\n                        <\/span>\r\n                        <span id=\"header-text-1536576333082\" class=\"accordions-head-title\">Adaptive Optics in Ophthalmology<\/span>\r\n                                        <\/div>\r\n                <div class=\"accordion-content content1536576333082 \">\r\n                    <p>Adaptive optics is a technique developed by astronomers to improve the image quality of celestial objects acquired by<br \/>\nground telescopes.<\/p>\n<p><img class=\"alignnone wp-image-1249\" src=\"http:\/\/www.visioeng.it\/wp-content\/uploads\/malattie-retina-2-324x375.jpg\" alt=\"\" width=\"220\" height=\"254\" \/><\/p>\n<p><strong>IMMAGINE<\/strong>\u00a0\u00a0Image of retinal photoreceptors. Adaptive optics allows to resolve individual retinal cells in vivo. Each cell has a diameter of a few micrometers. Thanks to adaptive optics, it will be possible to diagnose retinal pathologies early in the course of the disease, thus saving sight to millions of people.<\/p>\n                <\/div>\r\n                                <div post_id=\"1034\" itemcount=\"1\" header_id=\"header-0\" id=\"header-0\" style=\"\" class=\"accordions-head head0 border-none\" toggle-text=\"\" main-text=\"How Does Adaptive Optics Work\">\r\n                                            <span id=\"accordion-icons-0\" class=\"accordion-icons\">\r\n                            <span class=\"accordion-icon-active accordion-plus\"><i class=\"fa fa-plus\"><\/i><\/span>\r\n                            <span class=\"accordion-icon-inactive accordion-minus\"><i class=\"fa fa-minus\"><\/i><\/span>\r\n                        <\/span>\r\n                        <span id=\"header-text-0\" class=\"accordions-head-title\">How Does Adaptive Optics Work<\/span>\r\n                                        <\/div>\r\n                <div class=\"accordion-content content0 \">\r\n                    <p>Adaptive optics is a technology for correcting ocular optical aberrations. The current diagnostic tools of retinal and optic nerve diseases, such as OCT and ophthalmoscopy, are strongly limited by optical aberrations. Adaptive optics retinal imaging has a resolution 5 times higher than the best ophthalmic instruments currently used in clinic. It allows to observe the individual retinal microstructures, such as cells (photoreceptors), capillaries and nerve fibers. The new technology has been used for more than ten years and has provided new and significant knowledge of the anatomy and physiology of the retina and optic nerve.\u00a0 Adaptive optics retinal imaging will provide the eye doctors with a powerful tool for the early diagnosis of the most common eye diseases, such as macular dystrophies and glaucoma.<\/p>\n                <\/div>\r\n                                <div post_id=\"1034\" itemcount=\"2\" header_id=\"header-1536576467999\" id=\"header-1536576467999\" style=\"\" class=\"accordions-head head1536576467999 border-none\" toggle-text=\"\" main-text=\"Our Project\">\r\n                                            <span id=\"accordion-icons-1536576467999\" class=\"accordion-icons\">\r\n                            <span class=\"accordion-icon-active accordion-plus\"><i class=\"fa fa-plus\"><\/i><\/span>\r\n                            <span class=\"accordion-icon-inactive accordion-minus\"><i class=\"fa fa-minus\"><\/i><\/span>\r\n                        <\/span>\r\n                        <span id=\"header-text-1536576467999\" class=\"accordions-head-title\">Our Project<\/span>\r\n                                        <\/div>\r\n                <div class=\"accordion-content content1536576467999 \">\r\n                    <p>The co-founders of Vision Engineering Italy have been committed to the development of adaptive optics technology since 2002. The experience gained in these years is the strength of our staff. We have been collaborating with the most important research centers in the world aiming at accelerating the translation of this technology to clinic.\u00a0Since retinal and optic nerve diseases are currently diagnosed only after the onset of significant and irreversible retinal damages, the early diagnosis may represent the first step for treating tissue damage early in the course of the disease and protect sight. The development of methods and tools that are able to resolve the pathological changes of the retina at a cellular level is vital to achieve this objective.<\/p>\n                <\/div>\r\n                    <\/div>\r\n    <script>\r\n        jQuery(document).ready(function($){accordions_active_index_1034 = {\"1536576333082\":0};        })\r\n    <\/script><script type=\"application\/ld+json\">\r\n{\r\n    \"@context\": \"https:\/\/schema.org\",\r\n    \"@type\": \"FAQPage\",\r\n    \"mainEntity\": [{\r\n        \"@type\": \"Question\",\r\n        \"name\": \"Adaptive Optics in Ophthalmology\",\r\n        \"acceptedAnswer\":{\r\n            \"@type\": \"Answer\",\r\n            \"text\": \"Adaptive optics is a technique developed by astronomers to improve the image quality of celestial objects acquired by\r\nground telescopes.\r\n\r\n\r\n\r\nIMMAGINE\u00a0\u00a0Image of retinal photoreceptors. Adaptive optics allows to resolve individual retinal cells in vivo. Each cell has a diameter of a few micrometers. Thanks to adaptive optics, it will be possible to diagnose retinal pathologies early in the course of the disease, thus saving sight to millions of people.\"\r\n            }\r\n        },{\r\n        \"@type\": \"Question\",\r\n        \"name\": \"How Does Adaptive Optics Work\",\r\n        \"acceptedAnswer\":{\r\n            \"@type\": \"Answer\",\r\n            \"text\": \"Adaptive optics is a technology for correcting ocular optical aberrations. The current diagnostic tools of retinal and optic nerve diseases, such as OCT and ophthalmoscopy, are strongly limited by optical aberrations. Adaptive optics retinal imaging has a resolution 5 times higher than the best ophthalmic instruments currently used in clinic. It allows to observe the individual retinal microstructures, such as cells (photoreceptors), capillaries and nerve fibers. The new technology has been used for more than ten years and has provided new and significant knowledge of the anatomy and physiology of the retina and optic nerve.\u00a0 Adaptive optics retinal imaging will provide the eye doctors with a powerful tool for the early diagnosis of the most common eye diseases, such as macular dystrophies and glaucoma.\"\r\n            }\r\n        },{\r\n        \"@type\": \"Question\",\r\n        \"name\": \"Our Project\",\r\n        \"acceptedAnswer\":{\r\n            \"@type\": \"Answer\",\r\n            \"text\": \"The co-founders of Vision Engineering Italy have been committed to the development of adaptive optics technology since 2002. The experience gained in these years is the strength of our staff. We have been collaborating with the most important research centers in the world aiming at accelerating the translation of this technology to clinic.\u00a0Since retinal and optic nerve diseases are currently diagnosed only after the onset of significant and irreversible retinal damages, the early diagnosis may represent the first step for treating tissue damage early in the course of the disease and protect sight. The development of methods and tools that are able to resolve the pathological changes of the retina at a cellular level is vital to achieve this objective.\"\r\n            }\r\n        }]\r\n}\r\n<\/script>    <script>\r\n        jQuery(document).ready(function($){\r\n            accordion_1034  = $(\"#accordions-1034 .items\").accordion({\r\n                event: \"click\",\r\n                collapsible:true,\r\n                heightStyle: \"content\",\r\n                animate: (\"swing\", 1000),\r\n                navigation: true,\r\n                active: 999,\r\n                            });\r\n        })\r\n    <\/script>\r\n                <\/div>[\/vc_column_text][\/vc_column][vc_column width=&#8221;1\/2&#8243;][vc_custom_heading text=&#8221;Publications&#8221; font_container=&#8221;tag:h2|text_align:left|color:%2300c1cf&#8221; use_theme_fonts=&#8221;yes&#8221;][vc_column_text]\n<ul>\n<li><a href=\"\/wp-content\/uploads\/Mariotti-Analysis-of-Cone-Mosaic-Reflectance-Properties-in-diabetes.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Mariotti L, Devaney N, Lombardo G, Lombardo M. Analysis of cone mosaic reflectance properties in healthy eyes and in eyes with non-proliferative diabetic retinopathy over time. Invest Ophthalmol Vis Sci 2017;58(10):4057-4067.<\/a><\/li>\n<li><a href=\"\/wp-content\/uploads\/Giannini-Reliability-Agremment-between-cone-spacing-metrics.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Giannini D, Lombardo G, Mariotti L, Devaney N, Serrao S, Lombardo M. Reliability and agreement between metrics of cone spacing in adaptive optics images of the human retinal photoreceptor mosaic. Invest Ophthalmol Vis Sci 2017;58(7):3127-3137.<\/a><\/li>\n<li><a href=\"\/wp-content\/uploads\/Mariotti-Understading-cone-reflectance-changes-over-time_BOE.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Mariotti L, Devaney N, Lombardo G, Lombardo M. Understanding the changes of cone reflectance in adaptive optics flood illumination retinal images over 3 years. Biomed Opt Expr 2016; 7: 2807-2822.<\/a><\/li>\n<li><a href=\"\/wp-content\/uploads\/Methods-for-investigating-the-local-spatial-anisotropy_Vis-Neurosci.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Cooper RF, Lombardo M, Carroll J, Sloan KR, Lombardo G. Methods for investigating the local spatial anisotropy and the preferred orientation of cones in adaptive optics retinal images. Vis Neurosci 2016, 33: e005.<\/a><\/li>\n<li><a href=\"\/wp-content\/uploads\/AO-new-metrics-in-type-1-diabetes_Plos-One.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Lombardo M, Parravano M, Serrao S, Ziccardi L, Giannini D, Lombardo G. Investigation of Adaptive Optics Imaging Biomarkers for Detecting Pathological Changes of the Cone Mosaic in Patients with Type 1 Diabetes Mellitus. PLoS One 2016; 11(3):e0151380.<\/a><\/li>\n<li><a href=\"\/wp-content\/uploads\/AO-imaging-iERM-after-surgery_Retina.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Lombardo M, Scarinci F, Giannini D, Pileri M, Ripandelli G, Stirpe M, Lombardo G, Serrao S. High-resolution multimodal imaging following idiopathic epiretinal membrane surgery. Retina 2016; 36(1): 171-180.<\/a><\/li>\n<li><a href=\"\/wp-content\/uploads\/Multimodal-AO-OCT-imaging-of-OMD_Am-J-Ophthalmol-1.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Ziccardi L, Giannini D, Lombardo G, Serrao S, Dell\u2019Omo R, Nicoletti A, Bertelli M, Lombardo M. Multimodal approach to monitoring and investigating cone structure and function in an inherited macular dystrophy. Am J Ophthalmol, 2015; 160(2):301-312.e6<\/a><\/li>\n<li>Scarinci F, Lombardo M. Microscopic inner retinal hyperreflective structures in eyes with epiretinal membrane using adaptive optics scanning laser ophthalmoscopy. Retina 2020, Aug 3; E-published.<\/li>\n<li>Ziccardi L, Di Renzo A, Picconi F, Parisi V, Lombardo M, Frontoni S, Parravano M. Early and localized retinal dysfunction in patients with type 1 diabetes mellitus studied by multifocal electroretinogram. Acta Diabetologica 2018 Nov;55(11):1191-1200.<\/li>\n<\/ul>\n[\/vc_column_text][\/vc_column][\/vc_row][vc_row disable_element=&#8221;yes&#8221; css=&#8221;.vc_custom_1536589552666{margin-bottom: 110px !important;}&#8221;][vc_column width=&#8221;1\/2&#8243;][vc_column_text]Vision Engineering Italy \u00e8 impegnata nello sviluppo di metodi automatici ed intelligenti di diagnosi ultra-precoce delle patologie della retina.[\/vc_column_text][vc_tta_accordion style=&#8221;flat&#8221; shape=&#8221;square&#8221; color=&#8221;turquoise&#8221; active_section=&#8221;1&#8243; css_animation=&#8221;none&#8221; no_fill=&#8221;true&#8221; collapsible_all=&#8221;true&#8221;][vc_tta_section title=&#8221;Ottica adattiva in oftalmologia&#8221; tab_id=&#8221;1536589526357-6119359f-35fa&#8221;][vc_column_text]L\u2019ottica adattiva \u00e8 una tecnica sviluppata dagli astronomi per migliorare la qualit\u00e0 delle immagini degli oggetti celesti acquisite con i telescopi terrestri.<\/p>\n<p>Il primo prototipo di oftalmoscopio ad ottica adattiva \u00e8 stato progettato nei laboratori di Ottica della Visione nell\u2019Universit\u00e0 di Rochester (USA) nel 1996.[\/vc_column_text][vc_row_inner][vc_column_inner width=&#8221;1\/4&#8243;][vc_single_image image=&#8221;781&#8243; add_caption=&#8221;yes&#8221; onclick=&#8221;link_image&#8221;][\/vc_column_inner][vc_column_inner width=&#8221;3\/4&#8243;][vc_column_text]<em>Immagine dei fotorecettori retinici. La tecnologia ad ottica adattiva consente di risolvere le singole cellule retiniche in vivo. Ogni cellula ha diametro di pochi microni (1 micron = 1 millesimo di millimetro). Grazie all\u2019ottica adattiva sar\u00e0 presto possibile diagnosticare precocemente le malattie della retina e salvare la vista a milioni di persone in tutto il mondo.<\/em>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_tta_section][vc_tta_section title=&#8221;Come funziona l\u2019ottica adattiva&#8221; tab_id=&#8221;1536589527753-89c98e37-e124&#8243;][vc_column_text]L&#8217;ottica adattiva \u00e8 una tecnologia che consente la correzione delle aberrazioni ottiche oculari. Gli attuali strumenti di diagnostica delle malattie della retina e del nervo ottico, come l\u2019OCT e l\u2019oftalmoscopia laser, sono fortemente limitati dalle aberrazioni ottiche. L\u2019oftalmoscopia ad ottica adattiva ha una risoluzione 5 volte superiore rispetto ai migliori strumenti oggi in commercio. Consente di osserve le singole microstrutture retiniche, come le cellule (i fotorecettori), i capillari e le fibre nervose. La nuova tecnologia \u00e8 in uso clinico gi\u00e0 da una decina di anni ed ha fornito nuove e significative conoscenze dell\u2019anatomia e della fisiologia della retina e del nervo ottico; il suo scopo principale sar\u00e0 quello di fornire al medico oculista un potente strumento per la diagnosi precoce delle malattie pi\u00f9 frequenti dell\u2019occhio, come le maculopatie ed il glaucoma.[\/vc_column_text][vc_row_inner][vc_column_inner width=&#8221;1\/4&#8243;][vc_single_image image=&#8221;1032&#8243; img_size=&#8221;medium&#8221;][\/vc_column_inner][vc_column_inner width=&#8221;3\/4&#8243;][vc_column_text]<em>A sinistra un&#8217;immagine del fondo oculare acquisita con l&#8217;oftalmoscopia a scansione laser. Nella regione maculare \u00e8 sovraimposta l&#8217;immagine acquisista con l&#8217;oftalmoscopia ad Ottica Adattiva. In basso un dettaglio dello strato dei fotorecettori della macula<\/em>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_tta_section][vc_tta_section title=&#8221;Il nostro progetto&#8221; tab_id=&#8221;1536589529547-14369102-741e&#8221;][vc_column_text]I fondatori di Vision Engineering Italy sono impegnati nello sviluppo della tecnologia ad ottica adattiva sin dal 2002. L\u2019esperienza maturata in questi anni rappresenta il punto di forza del nostro staff che collabora con i pi\u00f9 importanti centri di ricerca nel mondo con l\u2019unico obiettivo di accelerare l\u2019uso clinico di questa tecnologia.<\/p>\n<p>Considerato che oggi, in moltissimi casi, le patologie retiniche e del nervo ottico sono diagnosticati solo dopo la comparsa di danni retinici significativi ed irreversibili, la diagnosi precoce pu\u00f2 rappresentare il primo passo al fine di curare precocemente i danni tissutali e salvaguardare la vista. Tutto ci\u00f2 comporta la necessit\u00e0 di sviluppare strumenti e metodi sensibili a cambiamenti specifici, come la perdita di fotorecettori. L\u2019aumento di contrasto ed il potere di risoluzione offerti dall&#8217;ottica adattiva sono in grado di raggiungere questo scopo.[\/vc_column_text][\/vc_tta_section][\/vc_tta_accordion][\/vc_column][vc_column width=&#8221;1\/2&#8243;][vc_custom_heading text=&#8221;Pubblicazioni&#8221; font_container=&#8221;tag:h2|text_align:left|color:%2300c1cf&#8221; use_theme_fonts=&#8221;yes&#8221;][vc_column_text]\n<ul>\n<li><a href=\"\/wp-content\/uploads\/Methods-for-investigating-the-local-spatial-anisotropy_Vis-Neurosci.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Cooper RF, Lombardo M, Carroll J, Sloan KR, Lombardo G. Methods for investigating the local spatial anisotropy and the preferred orientation of cones in adaptive optics retinal images. Vis Neurosci 2016, 33: e005.<\/a><\/li>\n<li><a href=\"\/wp-content\/uploads\/AO-new-metrics-in-type-1-diabetes_Plos-One.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Lombardo M, Parravano M, Serrao S, Ziccardi L, Giannini D, Lombardo G. Investigation of Adaptive Optics Imaging Biomarkers for Detecting Pathological Changes of the Cone Mosaic in Patients with Type 1 Diabetes Mellitus. PLoS One 2016; 11(3):e0151380.<\/a><\/li>\n<li><a href=\"\/wp-content\/uploads\/AO-imaging-iERM-after-surgery_Retina.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Lombardo M, Scarinci F, Giannini D, Pileri M, Ripandelli G, Stirpe M, Lombardo G, Serrao S. High-resolution multimodal imaging following idiopathic epiretinal membrane surgery. Retina 2016; 36(1): 171-180.<\/a><\/li>\n<li><a href=\"\/wp-content\/uploads\/Multimodal-AO-OCT-imaging-of-OMD_Am-J-Ophthalmol-1.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Ziccardi L, Giannini D, Lombardo G, Serrao S, Dell\u2019Omo R, Nicoletti A, Bertelli M, Lombardo M. Multimodal approach to monitoring and investigating cone structure and function in an inherited macular dystrophy. Am J Ophthalmol, 2015; 160(2):301-312.e6<\/a><\/li>\n<\/ul>\n[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_row disable_element=&#8221;yes&#8221;][vc_column][vc_single_image image=&#8221;1039&#8243; img_size=&#8221;large&#8221; style=&#8221;vc_box_shadow_border&#8221;][vc_column_text]\n<h3><strong>La cornea<\/strong><\/h3>\n<p>La cornea \u00e8 il tessuto trasparente pi\u00f9 esterno dell\u2019occhio umano e ne rappresenta la lente principale. Ogni alterazione del tessuto compromette fortemente la capacit\u00e0 visiva dell\u2019occhio.<\/p>\n<p>Il tessuto corneale \u00e8 costituito da cinque strati sovrapposti che, dall\u2019esterno verso l\u2019interno, sono rappresentati dall\u2019epitelio, la membrana di Bowman, lo stroma, la membrana di Descemet e l\u2019endotelio.<\/p>\n<p>L\u2019epitelio \u00e8 formato da una serie di strati cellulari sovrapposti; \u00e8 capace di rigenerarsi grazie all\u2019attivit\u00e0 delle cellule staminali situate nel limbus corneale. Lo stroma rappresenta la parte pi\u00f9 cospicua del tessuto corneale e provvede a mantenere le propriet\u00e0 meccaniche ed ottiche del tessuto. E\u2019 costituito di collagene. L\u2019endotelio \u00e8 costituito da un singolo strato di cellule la cui funzione \u00e8 quella di mantenere il corretto stato di idratazione del tessuto.[\/vc_column_text][vc_column_text]\n<h3><strong>Patologie della cornea<\/strong><\/h3>\n<p>Le alterazioni dell\u2019integrit\u00e0 e\/o della trasparenza del tessuto corneale rappresentano la terza causa globale di grave perdita della vista nel mondo. Traumi, infezioni o patologie genetiche possono compromettere il corretto funzionamento del tessuto e causare la perdita di trasparenza propria della cornea. Nonostante i continui progressi delle tecnologie oftalmiche, come l\u2019introduzione dell\u2019OCT e della Scheimpflug camera, ad oggi il principale componente della cornea, ovvero il collagene, rimane invisibile al medico oculistica!<\/p>\n<p>&nbsp;<\/p>\n<h3><strong>Il nostro progetto <\/strong><\/h3>\n<p>Vision Engineering Italy sta studiando una nuova soluzione altamente innovativa per la diagnosi precoce delle patologie corneali. Lo studio \u00e8 condotto in collaborazione con i pi\u00f9 importanti centri di ricerca in biofotonica e microscopia ad alta risoluzione in Europa. La tecnologia in via di sviluppo per l\u2019uso clinico \u00e8 basata sulla microscopia non lineare a due fotoni.[\/vc_column_text][\/vc_column][\/vc_row]\n<\/div> ","protected":false},"excerpt":{"rendered":"<p>[vc_section][vc_row][vc_column][vc_column_text] Methods and devices of early diagnosis of retinal diseases [\/vc_column_text][\/vc_column][\/vc_row][vc_row gap=&#8221;30&#8243;][vc_column offset=&#8221;vc_col-lg-offset-1 vc_col-lg-5 vc_col-md-offset-2 vc_col-md-8 vc_col-sm-offset-0 vc_col-xs-12&#8243;][vc_column_text][\/vc_column_text][\/vc_column][vc_column el_class=&#8221;aux-bus2-projects-column&#8221; offset=&#8221;vc_col-lg-offset-0 vc_col-lg-5 vc_col-md-offset-2 vc_col-md-8 vc_col-sm-offset-0 vc_col-xs-12&#8243;][vc_column_text][\/vc_column_text][\/vc_column][\/vc_row][vc_row css=&#8221;.vc_custom_1532705427259{margin-bottom: 110px !important;}&#8221;][vc_column width=&#8221;1\/2&#8243;][vc_column_text]Vision Engineering Italy is committed to the development of computerized methods for early detection of retinal diseases.[\/vc_column_text][vc_column_text][\/vc_column_text][\/vc_column][vc_column width=&#8221;1\/2&#8243;][vc_custom_heading text=&#8221;Publications&#8221; font_container=&#8221;tag:h2|text_align:left|color:%2300c1cf&#8221; use_theme_fonts=&#8221;yes&#8221;][vc_column_text] Mariotti L, Devaney N, Lombardo G, [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.visioeng.it\/en\/wp-json\/wp\/v2\/pages\/1031"}],"collection":[{"href":"https:\/\/www.visioeng.it\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.visioeng.it\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.visioeng.it\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.visioeng.it\/en\/wp-json\/wp\/v2\/comments?post=1031"}],"version-history":[{"count":7,"href":"https:\/\/www.visioeng.it\/en\/wp-json\/wp\/v2\/pages\/1031\/revisions"}],"predecessor-version":[{"id":1480,"href":"https:\/\/www.visioeng.it\/en\/wp-json\/wp\/v2\/pages\/1031\/revisions\/1480"}],"wp:attachment":[{"href":"https:\/\/www.visioeng.it\/en\/wp-json\/wp\/v2\/media?parent=1031"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}