{"id":1038,"date":"2018-07-27T10:05:15","date_gmt":"2018-07-27T10:05:15","guid":{"rendered":"\/\/www.visioeng.it\/microscopia-a-2-fotoni-per-la-diagnosi-precoce-della-malattie-della-cornea\/"},"modified":"2020-11-03T16:16:24","modified_gmt":"2020-11-03T16:16:24","slug":"methods-and-devices-of-early-diagnosis-of-corneal-diseases","status":"publish","type":"page","link":"https:\/\/www.visioeng.it\/en\/methods-and-devices-of-early-diagnosis-of-corneal-diseases\/","title":{"rendered":"Methods and Devices of early diagnosis of corneal diseases"},"content":{"rendered":"<div class=\"aux-vc-wrapper\" >[vc_section][vc_row][vc_column][vc_column_text]\n<h1 style=\"text-align: center;\">Methods and Devices of early diagnosis of corneal diseases<\/h1>\n[\/vc_column_text][\/vc_column][\/vc_row][vc_row gap=&#8221;30&#8243;][vc_column offset=&#8221;vc_col-lg-offset-1 vc_col-lg-5 vc_col-md-offset-2 vc_col-md-8 vc_col-sm-offset-0 vc_col-xs-12&#8243;][vc_column_text]<section class=\"aux-bus2-image-green-gradiant-reverse aux-bus2-image-radius-10px widget-container aux-widget-image aux-alignnone aux-parent-au7fe0c8a5\" style=\"\" >\n    <div class=\"aux-media-hint-frame \">\n        <div class=\"aux-media-image \" >\n        \n            \n\n                            <div class='aux-hover-scale-circle-plus'>\n                    <span class='aux-symbol-plus'><\/span>\n                    <span class='aux-symbol-circle'><\/span>\n                <\/div>\n            \n            <img width=\"777\" height=\"697\" src=\"https:\/\/www.visioeng.it\/wp-content\/uploads\/Progetti-2-fotoni-cornea-777x697.jpg\" class=\"aux-attachment aux-featured-image aux-attachment-id-779\" alt=\"Progetti - 2 fotoni cornea\" srcset=\"https:\/\/www.visioeng.it\/wp-content\/uploads\/Progetti-2-fotoni-cornea-200x179.jpg 200w,https:\/\/www.visioeng.it\/wp-content\/uploads\/Progetti-2-fotoni-cornea-500x449.jpg 500w,https:\/\/www.visioeng.it\/wp-content\/uploads\/Progetti-2-fotoni-cornea-768x689.jpg 768w,https:\/\/www.visioeng.it\/wp-content\/uploads\/Progetti-2-fotoni-cornea-777x697.jpg 777w\" data-ratio=\"1.11\" data-original-w=\"908\" sizes=\"(max-width:479px) 480px,(max-width:767px) 768px,(max-width:1023px) 1024px,777px\" \/>            \n                <\/div>\n    <\/div>\n\n<\/section><!-- widget-container -->[\/vc_column_text][\/vc_column][vc_column el_class=&#8221;aux-bus2-projects-column&#8221; offset=&#8221;vc_col-lg-offset-0 vc_col-lg-5 vc_col-md-offset-2 vc_col-md-8 vc_col-sm-offset-0 vc_col-xs-12&#8243;][vc_column_text]<section class=\"aux-bus2-projects-text aux-bus2-green-btn aux-parallax widget-container aux-widget-text aux-parent-au8e4c5543\" style=\"\" >        <div class=\"aux-widget-advanced-text aux-wrap-style-simple aux-ico-pos-top aux-text-left aux-text-resp-left aux-text-color-dark aux-text-widget-bg-center  \" style=\"background-color: #f9f9f9; \">\n        \n            \n            <div class=\"aux-text-inner aux-text-widget-content\">\n                                <div class=\"widget-content\">\n                                        \n<h3>2-photon microscopy for the early diagnosis of corneal diseases<\/h3>\n<div class=\"aux-bus2-title-divider\"><\/div>\n<p>\u00a0<\/p>\n<p>Vision Engineering Italy is a leader in translating innovative research to the clinic.<br \/>\n                <\/div>\n                            <\/div>\n        <\/div>\n                    <div class=\"aux-text-widget-footer\">\n                <div class=\"aux-border-shape-none \">\n                                <\/div>\n            <\/div>\n        \n<\/section><!-- widget-container -->[\/vc_column_text][\/vc_column][\/vc_row][vc_row css=&#8221;.vc_custom_1532705450541{margin-bottom: 110px !important;}&#8221;][vc_column width=&#8221;1\/2&#8243;][vc_column_text]<div id=\"accordions-1041\" class=\"accordions-1041 accordions\">\r\n                <style type='text\/css'>\r\n        @media only screen and (min-width: 1024px ){\r\n            #accordions-1041 {\r\n                            width: 100%;\r\n                        }\r\n        }\r\n        @media only screen and ( min-width: 768px ) and ( max-width: 1023px ) {\r\n            #accordions-1041 {\r\n                            width: 100%;\r\n                        }\r\n        }\r\n        @media only screen and ( min-width: 0px ) and ( max-width: 767px ){\r\n            #accordions-1041 {\r\n                            width: 100%;\r\n                        }\r\n        }\r\n        #accordions-1041 {\r\n                            text-align: left;\r\n                                                position: relative;\r\n        }\r\n        #accordions-1041 .accordions-head{\r\n                    background:#1bb0ce none repeat scroll 0 0;\r\n                                    outline: none;\r\n        }\r\n        #accordions-1041 .accordions-head-title{\r\n                            color:#ffffff;\r\n                            font-size:14px;\r\n                }\r\n        #accordions-1041 .accordions-head-title-toggle{\r\n                    color:#ffffff;\r\n                            font-size:14px;\r\n                }\r\n        #accordions-1041 .accordions-head:hover .accordions-head-title{\r\n                    color:#ffffff;\r\n                }\r\n        #accordions-1041 .ui-state-active{\r\n                    background: #00b3c0;\r\n                    border: none;\r\n        }\r\n        #accordions-1041 .accordion-content{\r\n                                    color:#333333;\r\n                            font-size:13px;\r\n                                    border: none;\r\n        }\r\n        #accordions-1041 .accordion-icons{\r\n                        color:#ffffff;\r\n                                    font-size:14px;\r\n                                                            margin:0px;\r\n                    }\r\n        #accordions-1041 .accordions-head:hover .accordion-icons span{\r\n                    }\r\n        #accordions-1041{}\r\n#accordions-1041 .accordions-head{font-family: &quot;Ubuntu&quot;; font-size: 1.375em; letter-spacing: 0;\r\n    font-weight: 600;}\r\n#accordions-1041 .accordion-content{font-family: &quot;Roboto&quot;; font-size: 1em; color: #444; line-height: 1.5;\r\n    font-style: normal;}    <\/style>\r\n    <div class=\"items\">\r\n                        <div post_id=\"1041\" itemcount=\"0\" header_id=\"header-1536576333082\" id=\"header-1536576333082\" style=\"\" class=\"accordions-head head1536576333082 border-none\" toggle-text=\"\" main-text=\" The Cornea\">\r\n                                            <span id=\"accordion-icons-1536576333082\" class=\"accordion-icons\">\r\n                            <span class=\"accordion-icon-active accordion-plus\"><i class=\"fa fa-plus\"><\/i><\/span>\r\n                            <span class=\"accordion-icon-inactive accordion-minus\"><i class=\"fa fa-minus\"><\/i><\/span>\r\n                        <\/span>\r\n                        <span id=\"header-text-1536576333082\" class=\"accordions-head-title\"> The Cornea<\/span>\r\n                                        <\/div>\r\n                <div class=\"accordion-content content1536576333082 \">\r\n                    <div class=\"wpb_text_column wpb_content_element \">\n<div class=\"wpb_wrapper\">\n<p style=\"text-align: left;\">The cornea is the outmost tissue of the human eye and represents its main objective lens. Any disease of the tissue may strongly compromises human vision. The corneal tissue consists of five layers which, from the outside to the inside, are represented by the epithelium, the Bowman\u2019s membrane, the stroma, the Descemet membrane and the endothelium. The epithelium consists of several cell layers; it is able to regenerate thanks to the activity of the limbal stem cells. The stroma represent the core of the tissue and is mainly composed of collagen.<\/p>\n<\/div>\n<\/div>\n                <\/div>\r\n                                <div post_id=\"1041\" itemcount=\"1\" header_id=\"header-0\" id=\"header-0\" style=\"\" class=\"accordions-head head0 border-none\" toggle-text=\"\" main-text=\"Corneal diseases\">\r\n                                            <span id=\"accordion-icons-0\" class=\"accordion-icons\">\r\n                            <span class=\"accordion-icon-active accordion-plus\"><i class=\"fa fa-plus\"><\/i><\/span>\r\n                            <span class=\"accordion-icon-inactive accordion-minus\"><i class=\"fa fa-minus\"><\/i><\/span>\r\n                        <\/span>\r\n                        <span id=\"header-text-0\" class=\"accordions-head-title\">Corneal diseases<\/span>\r\n                                        <\/div>\r\n                <div class=\"accordion-content content0 \">\r\n                    <div class=\"wpb_text_column wpb_content_element \">\n<div class=\"wpb_wrapper\">\n<p style=\"text-align: left;\">The pathologies of the corneal tissue represent the third global cause of serious vision loss worldwide. Trauma, infections or genetic diseases can compromise tissue integrity and may cause loss of corneal transparency. Despite continuous advances in ophthalmic technologies, there is not currently an ophthalmic instrument that may resolve the main component of the cornea, the collagen!<\/p>\n<\/div>\n<\/div>\n                <\/div>\r\n                                <div post_id=\"1041\" itemcount=\"2\" header_id=\"header-1536576467999\" id=\"header-1536576467999\" style=\"\" class=\"accordions-head head1536576467999 border-none\" toggle-text=\"\" main-text=\"Our Project\">\r\n                                            <span id=\"accordion-icons-1536576467999\" class=\"accordion-icons\">\r\n                            <span class=\"accordion-icon-active accordion-plus\"><i class=\"fa fa-plus\"><\/i><\/span>\r\n                            <span class=\"accordion-icon-inactive accordion-minus\"><i class=\"fa fa-minus\"><\/i><\/span>\r\n                        <\/span>\r\n                        <span id=\"header-text-1536576467999\" class=\"accordions-head-title\">Our Project<\/span>\r\n                                        <\/div>\r\n                <div class=\"accordion-content content1536576467999 \">\r\n                    <p style=\"text-align: left;\">Vision Engineering Italy is working on a novel highly innovative solution for the early diagnosis of corneal diseases. The study is conducted in collaboration with the most important research centers in biophotonics and high resolution microscopy accross Europe. The technology is based on two-photon non-linear microscopy.<\/p>\n                <\/div>\r\n                    <\/div>\r\n    <script>\r\n        jQuery(document).ready(function($){accordions_active_index_1041 = {\"1536576333082\":0};        })\r\n    <\/script><script type=\"application\/ld+json\">\r\n{\r\n    \"@context\": \"https:\/\/schema.org\",\r\n    \"@type\": \"FAQPage\",\r\n    \"mainEntity\": [{\r\n        \"@type\": \"Question\",\r\n        \"name\": \"The Cornea\",\r\n        \"acceptedAnswer\":{\r\n            \"@type\": \"Answer\",\r\n            \"text\": \"The cornea is the outmost tissue of the human eye and represents its main objective lens. Any disease of the tissue may strongly compromises human vision. The corneal tissue consists of five layers which, from the outside to the inside, are represented by the epithelium, the Bowman\u2019s membrane, the stroma, the Descemet membrane and the endothelium. The epithelium consists of several cell layers; it is able to regenerate thanks to the activity of the limbal stem cells. The stroma represent the core of the tissue and is mainly composed of collagen.\"\r\n            }\r\n        },{\r\n        \"@type\": \"Question\",\r\n        \"name\": \"Corneal diseases\",\r\n        \"acceptedAnswer\":{\r\n            \"@type\": \"Answer\",\r\n            \"text\": \"The pathologies of the corneal tissue represent the third global cause of serious vision loss worldwide. Trauma, infections or genetic diseases can compromise tissue integrity and may cause loss of corneal transparency. Despite continuous advances in ophthalmic technologies, there is not currently an ophthalmic instrument that may resolve the main component of the cornea, the collagen!\"\r\n            }\r\n        },{\r\n        \"@type\": \"Question\",\r\n        \"name\": \"Our Project\",\r\n        \"acceptedAnswer\":{\r\n            \"@type\": \"Answer\",\r\n            \"text\": \"Vision Engineering Italy is working on a novel highly innovative solution for the early diagnosis of corneal diseases. The study is conducted in collaboration with the most important research centers in biophotonics and high resolution microscopy accross Europe. The technology is based on two-photon non-linear microscopy.\"\r\n            }\r\n        }]\r\n}\r\n<\/script>    <script>\r\n        jQuery(document).ready(function($){\r\n            accordion_1041  = $(\"#accordions-1041 .items\").accordion({\r\n                event: \"click\",\r\n                collapsible:true,\r\n                heightStyle: \"content\",\r\n                animate: (\"swing\", 1000),\r\n                navigation: true,\r\n                active: 999,\r\n                            });\r\n        })\r\n    <\/script>\r\n                <\/div>[\/vc_column_text][\/vc_column][vc_column width=&#8221;1\/2&#8243; css=&#8221;.vc_custom_1532687870433{margin-top: -80px !important;}&#8221;][vc_custom_heading text=&#8221;Publications&#8221; font_container=&#8221;tag:h2|text_align:left|color:%2300c1cf&#8221; use_theme_fonts=&#8221;yes&#8221;][vc_column_text]\n<ul>\n<li><a href=\"\/wp-content\/uploads\/Nanotech-riboflavin-for-corneal-cross-linking_JCRS.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Lombardo G, Micali NL, Villari V, Leone N, Rusciano D, Serrao S, Lombardo M. Assessment of stromal riboflavin concentration-depth profile in nanotechnology-based transepithelial corneal cross-linking. J Cataract Refract Surg 2017;43(5):680-686.<\/a><\/li>\n<li><a href=\"\/wp-content\/uploads\/Two-photon-optical-microscopy-imaging-of-endothelial-keratoplasty-grafts_Graefes.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Lombardo M, Parekh M, Serrao S, Ruzza A, Ferrari S, Lombardo G. Two-photon optical microscopy imaging of endothelial keratoplasty grafts. Graefe&#8217;s Arch Clin Exp Ophthalmol 2017; 255(3):575-582<\/a><\/li>\n<li><a href=\"\/wp-content\/uploads\/All-optical-method-TPEF-ribo-in-CXL_IOVS.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Lombardo M, Micali N, Villari V, Serrao S, Lombardo G All-optical method to assess stromal concentration of riboflavin in conventional and accelerated UV-A irradiation of the human cornea. Invest Opthalmol Vis Sci 2016; 57(2): 476-483.<\/a><\/li>\n<li><a href=\"\/wp-content\/uploads\/Translation-label-free-biomarkers-of-the-cornea_BOE.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Lombardo M, Merino D, Loza-Alvarez P, Lombardo G. Translational label-free nonlinear imaging biomarkers to classify the human corneal microstructure. Biomed Opt Express 2015; 8;6(8):2803-18.<\/a><\/li>\n<li><a href=\"\/wp-content\/uploads\/Multiscale-investigation-corneal-anisotropy_IOVS.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Labate C, Lombardo M, De Santo MP, Dias J, Ziebarth N, Lombardo G. Multiscale investigation of the depth-dependent mechanical anisotropy of the human corneal stroma. Invest Ophthalmol Vis Sci 2015; 56: 4053-4060.<\/a><\/li>\n<li><a href=\"\/wp-content\/uploads\/boe-pSHG-cornea-kconus.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Alizadeh M, Merino D, Lombardo G, Lombardo M, Mencucci R, Ghotbi M, Alvarez P. Identifying crossing collagen fibers in human corneal tissues using pSHG images. Biomed Opt Expr 2019 Jul 10;10(8):3875-3888.<\/a><\/li>\n<\/ul>\n[\/vc_column_text][\/vc_column][\/vc_row][vc_row disable_element=&#8221;yes&#8221; css=&#8221;.vc_custom_1536590280302{margin-bottom: 110px !important;}&#8221;][vc_column width=&#8221;1\/2&#8243;][vc_tta_accordion style=&#8221;flat&#8221; shape=&#8221;square&#8221; color=&#8221;turquoise&#8221; active_section=&#8221;1&#8243; no_fill=&#8221;true&#8221;][vc_tta_section title=&#8221;La Cornea&#8221; tab_id=&#8221;1536590248653-389c7905-a057&#8243;][vc_column_text]La cornea \u00e8 il tessuto trasparente pi\u00f9 esterno dell\u2019occhio umano e ne rappresenta la lente principale. Ogni alterazione del tessuto compromette fortemente la capacit\u00e0 visiva dell\u2019occhio.<\/p>\n<p>Il tessuto corneale \u00e8 costituito da cinque strati sovrapposti che, dall\u2019esterno verso l\u2019interno, sono rappresentati dall\u2019epitelio, la membrana di Bowman, lo stroma, la membrana di Descemet e l\u2019endotelio.<\/p>\n<p>L\u2019epitelio \u00e8 formato da una serie di strati cellulari sovrapposti; \u00e8 capace di rigenerarsi grazie all\u2019attivit\u00e0 delle cellule staminali situate nel limbus corneale. Lo stroma rappresenta la parte pi\u00f9 cospicua del tessuto corneale e provvede a mantenere le propriet\u00e0 meccaniche ed ottiche del tessuto. E\u2019 costituito di collagene. L\u2019endotelio \u00e8 costituito da un singolo strato di cellule la cui funzione \u00e8 quella di mantenere il corretto stato di idratazione del tessuto.[\/vc_column_text][\/vc_tta_section][vc_tta_section title=&#8221;Patologie della cornea&#8221; tab_id=&#8221;1536590249082-9753ea13-652f&#8221;][vc_column_text]Le alterazioni dell\u2019integrit\u00e0 e\/o della trasparenza del tessuto corneale rappresentano la terza causa globale di grave perdita della vista nel mondo. Traumi, infezioni o patologie genetiche possono compromettere il corretto funzionamento del tessuto e causare la perdita di trasparenza propria della cornea. Nonostante i continui progressi delle tecnologie oftalmiche, come l\u2019introduzione dell\u2019OCT e della Scheimpflug camera, ad oggi il principale componente della cornea, ovvero il collagene, rimane invisibile al medico oculistica![\/vc_column_text][\/vc_tta_section][vc_tta_section title=&#8221;Il nostro progetto&#8221; tab_id=&#8221;1536590249609-13dd0188-dd90&#8243;][vc_column_text]Vision Engineering Italy sta studiando una nuova soluzione altamente innovativa per la diagnosi precoce delle patologie corneali. Lo studio \u00e8 condotto in collaborazione con i pi\u00f9 importanti centri di ricerca in biofotonica e microscopia ad alta risoluzione in Europa. La tecnologia in via di sviluppo per l\u2019uso clinico \u00e8 basata sulla microscopia non lineare a due fotoni.[\/vc_column_text][\/vc_tta_section][\/vc_tta_accordion][\/vc_column][vc_column width=&#8221;1\/2&#8243; css=&#8221;.vc_custom_1532687870433{margin-top: -80px !important;}&#8221;][vc_custom_heading text=&#8221;Pubblicazioni&#8221; font_container=&#8221;tag:h2|text_align:left|color:%2300c1cf&#8221; use_theme_fonts=&#8221;yes&#8221;][vc_column_text]\n<ul>\n<li><a href=\"\/wp-content\/uploads\/Nanotech-riboflavin-for-corneal-cross-linking_JCRS.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Lombardo G, Micali NL, Villari V, Leone N, Rusciano D, Serrao S, Lombardo M. Assessment of stromal riboflavin concentration-depth profile in nanotechnology-based transepithelial corneal cross-linking. J Cataract Refract Surg 2017;43(5):680-686.<\/a><\/li>\n<li><a href=\"\/wp-content\/uploads\/Two-photon-optical-microscopy-imaging-of-endothelial-keratoplasty-grafts_Graefes.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Lombardo M, Parekh M, Serrao S, Ruzza A, Ferrari S, Lombardo G. Two-photon optical microscopy imaging of endothelial keratoplasty grafts. Graefe&#8217;s Arch Clin Exp Ophthalmol 2017; 255(3):575-582<\/a><\/li>\n<li><a href=\"\/wp-content\/uploads\/All-optical-method-TPEF-ribo-in-CXL_IOVS.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Lombardo M, Micali N, Villari V, Serrao S, Lombardo G All-optical method to assess stromal concentration of riboflavin in conventional and accelerated UV-A irradiation of the human cornea. Invest Opthalmol Vis Sci 2016; 57(2): 476-483.<\/a><\/li>\n<li><a href=\"\/wp-content\/uploads\/Translation-label-free-biomarkers-of-the-cornea_BOE.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Lombardo M, Merino D, Loza-Alvarez P, Lombardo G. Translational label-free nonlinear imaging biomarkers to classify the human corneal microstructure. Biomed Opt Express 2015; 8;6(8):2803-18.<\/a><\/li>\n<li><a href=\"\/wp-content\/uploads\/Multiscale-investigation-corneal-anisotropy_IOVS.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Labate C, Lombardo M, De Santo MP, Dias J, Ziebarth N, Lombardo G. Multiscale investigation of the depth-dependent mechanical anisotropy of the human corneal stroma. Invest Ophthalmol Vis Sci 2015; 56: 4053-4060.<\/a><\/li>\n<\/ul>\n[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_row disable_element=&#8221;yes&#8221;][vc_column][vc_single_image image=&#8221;1039&#8243; img_size=&#8221;large&#8221; style=&#8221;vc_box_shadow_border&#8221;][vc_column_text]\n<h3><strong>La cornea<\/strong><\/h3>\n<p>La cornea \u00e8 il tessuto trasparente pi\u00f9 esterno dell\u2019occhio umano e ne rappresenta la lente principale. Ogni alterazione del tessuto compromette fortemente la capacit\u00e0 visiva dell\u2019occhio.<\/p>\n<p>Il tessuto corneale \u00e8 costituito da cinque strati sovrapposti che, dall\u2019esterno verso l\u2019interno, sono rappresentati dall\u2019epitelio, la membrana di Bowman, lo stroma, la membrana di Descemet e l\u2019endotelio.<\/p>\n<p>L\u2019epitelio \u00e8 formato da una serie di strati cellulari sovrapposti; \u00e8 capace di rigenerarsi grazie all\u2019attivit\u00e0 delle cellule staminali situate nel limbus corneale. Lo stroma rappresenta la parte pi\u00f9 cospicua del tessuto corneale e provvede a mantenere le propriet\u00e0 meccaniche ed ottiche del tessuto. E\u2019 costituito di collagene. L\u2019endotelio \u00e8 costituito da un singolo strato di cellule la cui funzione \u00e8 quella di mantenere il corretto stato di idratazione del tessuto.[\/vc_column_text][vc_column_text]\n<h3><strong>Patologie della cornea<\/strong><\/h3>\n<p>Le alterazioni dell\u2019integrit\u00e0 e\/o della trasparenza del tessuto corneale rappresentano la terza causa globale di grave perdita della vista nel mondo. Traumi, infezioni o patologie genetiche possono compromettere il corretto funzionamento del tessuto e causare la perdita di trasparenza propria della cornea. Nonostante i continui progressi delle tecnologie oftalmiche, come l\u2019introduzione dell\u2019OCT e della Scheimpflug camera, ad oggi il principale componente della cornea, ovvero il collagene, rimane invisibile al medico oculistica!<\/p>\n<p>&nbsp;<\/p>\n<h3><strong>Il nostro progetto <\/strong><\/h3>\n<p>Vision Engineering Italy sta studiando una nuova soluzione altamente innovativa per la diagnosi precoce delle patologie corneali. Lo studio \u00e8 condotto in collaborazione con i pi\u00f9 importanti centri di ricerca in biofotonica e microscopia ad alta risoluzione in Europa. La tecnologia in via di sviluppo per l\u2019uso clinico \u00e8 basata sulla microscopia non lineare a due fotoni.[\/vc_column_text][\/vc_column][\/vc_row]\n<\/div> ","protected":false},"excerpt":{"rendered":"<p>[vc_section][vc_row][vc_column][vc_column_text] Methods and Devices of early diagnosis of corneal diseases [\/vc_column_text][\/vc_column][\/vc_row][vc_row gap=&#8221;30&#8243;][vc_column offset=&#8221;vc_col-lg-offset-1 vc_col-lg-5 vc_col-md-offset-2 vc_col-md-8 vc_col-sm-offset-0 vc_col-xs-12&#8243;][vc_column_text][\/vc_column_text][\/vc_column][vc_column el_class=&#8221;aux-bus2-projects-column&#8221; offset=&#8221;vc_col-lg-offset-0 vc_col-lg-5 vc_col-md-offset-2 vc_col-md-8 vc_col-sm-offset-0 vc_col-xs-12&#8243;][vc_column_text][\/vc_column_text][\/vc_column][\/vc_row][vc_row css=&#8221;.vc_custom_1532705450541{margin-bottom: 110px !important;}&#8221;][vc_column width=&#8221;1\/2&#8243;][vc_column_text][\/vc_column_text][\/vc_column][vc_column width=&#8221;1\/2&#8243; css=&#8221;.vc_custom_1532687870433{margin-top: -80px !important;}&#8221;][vc_custom_heading text=&#8221;Publications&#8221; font_container=&#8221;tag:h2|text_align:left|color:%2300c1cf&#8221; use_theme_fonts=&#8221;yes&#8221;][vc_column_text] Lombardo G, Micali NL, Villari V, Leone N, Rusciano D, Serrao S, Lombardo M. Assessment of stromal riboflavin concentration-depth [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.visioeng.it\/en\/wp-json\/wp\/v2\/pages\/1038"}],"collection":[{"href":"https:\/\/www.visioeng.it\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.visioeng.it\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.visioeng.it\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.visioeng.it\/en\/wp-json\/wp\/v2\/comments?post=1038"}],"version-history":[{"count":4,"href":"https:\/\/www.visioeng.it\/en\/wp-json\/wp\/v2\/pages\/1038\/revisions"}],"predecessor-version":[{"id":1486,"href":"https:\/\/www.visioeng.it\/en\/wp-json\/wp\/v2\/pages\/1038\/revisions\/1486"}],"wp:attachment":[{"href":"https:\/\/www.visioeng.it\/en\/wp-json\/wp\/v2\/media?parent=1038"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}